Aspirin antagonism in isoniazid treatment of tuberculosis in mice.
نویسندگان
چکیده
Salicylate has previously been shown to reduce the susceptibility of Mycobacterium tuberculosis to several drugs in vitro. In this study, aspirin, a salicylate anti-inflammatory, antagonized isoniazid treatment of murine pulmonary tuberculosis, whereas the nonsalicylate ibuprofen did not. These results may have implications on concurrent administration of anti-inflammatory and antituberculosis drugs.
منابع مشابه
The treatment of leprosy with thiosemicarbazone.
REFERENCES 1. W. S. DAVIDSON: .. Evaluation of New Treatments" Lep. Rev. XXIV, 139, 1953. 2. E. GRUNBERG and R. J. SCHNITZER: .. Antagonism of Isoniazid and Strepto mycin in Experimental Infection of Mice with M. Tuberculosis H37Rv." America// Rev. of Tubermlosis, Vol. 68. 277. 1953. 3. W. SZYBALSKI and V. BRYSON: .. Conditional Antagonism between Isoniazid and other Antibacterial Agents." Ibi...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 51 2 شماره
صفحات -
تاریخ انتشار 2007